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Science Journal

 

New York Science Journal

(N Y Sci J)

ISSN 1554-0200 (print); ISSN 2375-723X (online), doi:10.7537/j.issn.1554-0200, Monthly

Volume 8 - Number 6 (Cumulated No. 76); June 25, 2015

Cover Page, Introduction, Contents, Call for Papers, ny0806

 

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CONTENTS  

No.

Titles / Authors /Abstracts

Full Text

No.

1

Compensate for the loss of non-profit

 

Ali Bazmi Haji Khajehlou1, Davar Tohidi1, Mohammad Reza Marandi2

 

1. MSc student in private law, Islamic Azad University, Germi Branch, Ardabil, Iran

2. Lecturer in Islamic Azad University, Germi Branch, Ardabil, Iran

 

Abstract: Non-profit group of jurists and lawyers know the loss compensation benefits, and it is not and does not guarantee it count. But another set up for it by treating it as a loss to know. At this point it should be noted that the law on non-profit ideas clearly expressed opposition or not. It is derived from the common law in certain instances, strengthen benefits are realized. For example, stunting his imprisonment artisans who make the daily business of living, Examples of deprivation of educational benefits realized that there are different opinions about the liability of its binding. In this section we evaluate the need to compensate for the loss of non-profit focused on jurisprudence and law various theories have been proposed in this field, we have analyzed and appropriate responses to the questions on that. (1). Foundations and documentation necessary to compensate for the loss of non-profit in Islamic jurisprudence is? (2). Principles and legal documentation necessary to compensate for the loss of rights is non-profit. (3). The terms of compensation for loss of Islamic law and the rights of non-profit in Iran? (4). The non-profit status or benefits may be obtained on Islamic law and the rights of Iran?

[Ali Bazmi Haji Khajehlou, Davar Tohidi, Mohammad Reza Marandi. Compensate for the loss of non-profit. N Y Sci J 2015;8(6):1-5]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 1

doi:10.7537/marsnys080615.01

 

Keywords: Loss of non-profit, Law, Islamic jurisprudence

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2

The role of mothers' schemas on adolescent girls' sex education

 

Masoumeh Masoumi1, Shima Malekzadeh1, Elham AbNiki2, Fahimeh Barkhordari3

 

1. MA in Educational Psychology, Alzahra University, Tehran, Iran

2. Researcher and psychologist at Islamic Republic of Iran Broadcasting (IRIB), Ph.D. student of General Psychology, University of Mohaghegh Ardabili, Ardabil, Iran

3. Ph.D. student of General Psychology, University of Mohaghegh Ardabili, Ardabil, Iran

 

Abstract: Among the family members, the mother can be for a child usually spends more time with him and it is the first coach he can be considered the most important person in this field. On the other hand, the mother's lifestyle can be seen from his scheme. 6 students and their mother were interviewed. The data were using analyzed qualitative content analyzer. The findings descript mothers schema play a critical role in several aspects of how they do the sex education of their young daughters. Mothers' schema also is significant in the attitude of students to marriage and gender role. Furthermore findings show mothers schemas play a critical role in how to she answered their daughters question about sex, the reaction to their puberty, and the characteristics of this period such as the tendency to communicate with opposite sex.

[Masoumeh Masoumi, Shima Malekzadeh, Elham AbNiki, Fahimeh Barkhordari. The role of mothers' schemas on adolescent girls' sex education. N Y Sci J 2015;8(6):6-10]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 2

doi:10.7537/marsnys080615.02

 

Keywords: role of mothers, schemas, sex education

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3

Sense of place from the perspective of urban signs based on citizens' viewpoint (Case Study: Elements of Minoodar square in Qazvin)

 

Abolfazl Karbalaei Hosseini Ghiasvand1*, Ramezanali Shormeyj2

 

1* Master of Architecture, Islamic Azad University of Shahrood, Semnan, Iran (Corresponding author)

2 Urban Ph.D., assistant professor of Architecture and urban faculty, Islamic Azad University of Qazvin, Qazvin, Iran

Aqiyasvand@yahoo.com

 

Abstract: Physical appearance, actions and meanings, raw materials are places identity. Another aspect of the identity of the place is important but within the elements of human interaction with these forms. Urban elements through physical and visual characteristics, an important role in the creation of images, the citizens of the city is considered. The factors contributing to a sense of place in the citizens of these elements can have a significant impact on urban identity and utility fields. Based on the importance of creating a sense of place identity, location and quality of the environment, the study also examined the concept of a sense of place and its dimensions, the role of the different aspects in creating a sense of place and identity elements of urban utility checks. Given the importance of creating a sense of place identity, location and quality of the environment, the study also examined the concept of a sense of place and its dimensions, the role of the different aspects in creating a sense of place and identity elements of urban utility checks. The population of citizens of the city of Qazvin which 100 were selected by random sampling as a society is vital. Methods used in this research are descriptive and analytical - and the data collection was performed in combination. In the first stage using library resources and documents extracted theoretical knowledge of literature was obtained. In the second phase, which was conducted as a survey, a questionnaire was developed according to the literature the first part of its citizens were collected data from questionnaires were analyzed by spss software version 19. The recognition of different dimensions of the sense of place and the role of each of these aspects in creating a sense of place and identity, urban element to ensure citizens is important.

[Abolfazl Karbalaei Hosseini Ghiasvand, Ramezanali Shormeyj. Sense of place from the perspective of urban signs based on citizens' viewpoint (Case Study: Elements of Minoodar square in Qazvin). N Y Sci J 2015;8(6):11-18]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 3

doi:10.7537/marsnys080615.03

 

Keywords: Qazvin, Urban marks, Elements, a sense of place, place identity

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4

Investigation role of Information Technology (IT) in urban management transformation

 

Hosein Esmaeili Niasan

 

Postgraduate degree in Information Technology Management, Islamic Azad University, E campus

 

Abstract: This study investigated the role of information technology in urban management and its transform, construed either as evolutionary or revolutionary, permeates two broad urban research traditions of metropolitan change. It reviews research findings from these two research traditions concerning metropolitan population and employment redistribution. It suggests that synergies between ICT and our car, truck, and airplane society may be a thrust behind well-established urban decentralization and deconcentration trends. Because creating electronic city and electronic municipality that they are result of information technology, causes citizens access to their needed services directly, safe, reliable, quickly and 7-24, and physical offices replace by digital offices and organizations such as municipality, public transportation, regional water organization, etc provide their services virtually and using facilitates such as ICT for citizens. However, such logic poses serious challenges to smart growth’s metropolitan agenda. Although both centrifugal and centripetal forces are shaping the form of the information age metropolis, rather than central city renaissance or absolute urban dissolution, the resulting spatially distributed network pattern is polycentric and evolving into a regional constellation of ICT agglomerations interconnected via high-speed transportation and digital networks.

[Hosein Esmaeili Niasan. Investigation role of Information Technology (IT) in urban management transformation. N Y Sci J 2015;8(6):19-27]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 4

doi:10.7537/marsnys080615.04

 

Keywords: Information Technology, urban management, ICT-intensive firms

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5

Investigation the relationship between social responsibility and organizational citizenship behavior (Case study: Tehran Municipality Organization)

 

Hamed Asl Hadad1, Kewmars Fallahi2

  

1.  Msc in Business Management, Islamic Azad University North Tehran Branch

2. Faculty member, Institute for Educational Research Academy of Scientific in Education and Commercial Management Department, Management and social sciences Faculty, Tehran North Branch Islamic  Azad University, Tehran, Iran

 

Abstract: The concept of corporate social responsibility in recent years in the field of corporate governance has become a dominant paradigm. This responsibility requires the simultaneous realization of economic responsibility, legal, moral and humanitarian company. More practical in terms of corporate social responsibility for profitability, comply with the law, ethics and try to be a good citizen. Now that you understand the importance of citizens as one of the most important resources are, their behavior can also be considered the result very important objective of this study was to investigate the relationship between corporate social responsibility and citizenship behavior. The population of this study included all administrative employees of the Central Organization of Tehran Municipality; the number of these 300 was estimated. Due to the size of the population, the sample size of 170 was obtained. Method of data collection questionnaire and software for data analysis and PLS structural equation method is used. Results from this study showed that social responsibility and citizenship behavior (altruism, conscientiousness, generosity, respect and honor and civic virtue). For all the hypothesis of social responsibility in citizens' behavior was positive. As well as social responsibility and social responsibility, respect and reverence have the greatest impact on the fairness.

[Hamed Asl Hadad, Kiumars Fallahi. Investigation the relationship between social responsibility and organizational citizenship behavior (Case study: Tehran Municipality Organization). N Y Sci J 2015;8(6):28-34]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 5

doi:10.7537/marsnys080615.05

 

Keywords: social responsibility, citizenship behavior, loyalty, respect and honor and civic virtue

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6

Provide guidance to choose appropriate method to evaluate human error

 

Saeid Maddah1, Mehdi Ghasemi2

 

1. University of Malaya, Kuala lampur, Malaysia

2. Medical Science, Tehran University, Tehran, Iran

 

Abstract: To reduce human error in the context of the need for a separate risk assessment to assess the risks arising from human error that this need can be identified using the techniques of human error and human reliability analysis provided. In this paper, an overview of the methods of analysis paid to human error. The aim of this study is to provide guidance to select the appropriate method for determining human error in the workplace, according to the circumstances, needs and limitations for each person is performing. Data collection methods in the study of literature and case studies carried out in this field. 10 techniques that are used to select high accuracy using criteria that are commonly used for the analysis and systems are important to choose the right method (eg, comprehensiveness, accuracy, consistency and output methods) are compared with each other. For comparison criteria used by professionals, human reliability analysis and human factors are important for meaningful review and analysis techniques, human error is proven. The results of this research can be a fast and logical model to select the appropriate method for the analysis of human errors on different working environments to be used.

[Saeid Maddah, Mehdi Ghasemi. Provide guidance to choose appropriate method to evaluate human error. N Y Sci J 2015;8(6):35-41]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 6

doi:10.7537/marsnys080615.06

 

Keywords: human error, human reliability, quantitative assessment of risk

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7

Evolution in the Limbo life in Mulla Sadra's view

 

Mahdieh Alsadat Omrani1, Esmaeil Zarei Hajiabadi2, Mohammad Hossein Mahdavinejad3, Abdollah Forouzanfar4

                                                                                                                                                                                                                                                      

1. Faculty member of Hormozgan University, PhD student of Payame Noor University (PNU), lecturer of Islamic Studies

2. Assistant Professor in Theology, Faculty member of Payame Noor University of Bandar Abbas

3. Assistant Professor, Faculty member of Payame Noor University of Yazd

4. Assistant Professor, Faculty member of Hormozgan University

 

Abstract: Many of the teachings of Islam based on the essence of man after death continues, and since the problem of authority and reason in Islamic philosophy and theology still considered radical views, so a lot of the soul, wisdom and determination of all human perfection is self-initiated, an eternal truth is considered.  And powers and shall also be eternal and as breath in a worldly sense and decide on the matter in limbo ability. Thus human evolution is more depending on the choice between good and good in this selection, worldly life he has with them can be a major cause. Mulla Sadra is also spoken in some cases, such as if the evolution of the soul in the spiritual worlds which is accepted. Since the modern man of great moral challenges, such as the meaning of life, suffering and pain in this world is facing, evolution Purgatory and necessary to provide that in limbo, it can be effective to achieve human happiness. This paper is an attempt to explain the micro-friendly moves within transcendental philosophy.

[Mahdieh Alsadat Omrani, Esmaeil Zarei Hajiabadi, Mohammad Hossein Mahdavinejad, Abdollah Forouzanfar. Evolution in the Limbo life in Mulla Sadra's view. N Y Sci J 2015;8(6):42-48]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 7

doi:10.7537/marsnys080615.07

 

Keywords: Purgatory, Authority, evolution of limbo, moving ink

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8

Examine the consequences of the use of information and communication technology (ICT) in curriculum of girls' smart school in Tehran, 2013-2014

 

Fatemeh Khojasteh1, Effat Abbasi2

 

1. Student at Kharazmi University in Tehran

2. Faculty member of Kharazmi University in Tehran

 

Abstract: The purpose of this study was to evaluate the consequences of the use of ICT in the curriculum smart girls' high schools in Tehran, according to Klein is nine elements. Combination method was used. Data from qualitative interviews and quantitative data were collected through questionnaires, five-point Likert. The subjects in the quality of professionals, teachers, and students who knew more than other forms of ICT tools. Snowball sampling method and sampling was conducted until data saturation. The population consists of professionals, including teachers in some public universities of Tehran, Tehran's experts twenty of which samples of society. Smart girl students as well as teachers and District 6 of Tehran. The results of the interviews show that the use of ICT in the curriculum smart schools, which are the positive and negative consequences are as follows: Positive consequences: Facilitate the realization of the goals of using ICT tools, the impact on the three areas of cognitive, affective, psychomotor, electronic content to increase the quality of content, and engaging the various methods, the use of different senses, The evaluation of the pencil, paper, electronic evaluation, self-evaluation of students, evaluation of a variety of forms, wide and interesting variety of resources, digitization of resources, enhance the quality of learning deepens learning using multiple resources, diversification of learning activities, Grouping participatory learning process, attention to individual differences in the grouping, cross-grouping. Negative consequences: Teachers in various ways to create resistance against distrust for exams online, allowing more students cheating in exams online. Failure to appear for exams teachers lack sufficient skills online/ student confusion in the selection of the group, eliminating discrimination, non-prescription group, participation in community groups at the international level. The results of the quantitative data are the opinions of experts, teachers and students on the implications of the use of ICT but there is agreement on a set curriculum evaluation.

[Fatemeh Khojasteh, Effat Abbasi. Examine the consequences of the use of information and communication technology (ICT) in curriculum of girls' smart school in Tehran, 2013-2014. N Y Sci J 2015;8(6):49-53]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 8

doi:10.7537/marsnys080615.08

 

Keywords: ICT, smart schools, curriculum

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9

The Study of Flatness and Timeliness of Financial Information on Pricing the irrational stock

 

Mohammad saadatniya 1, Dr. Mohammad Tamimi 2

 

1.  Department of Accounting, Persian Gulf International Branch, Islamic Azad university, khorramshahr, iran

2.  Assistant Professor, Department of Accounting, Dezful Branch, Islamic Azad university, Dezful, Iran

 

Abstract: One way to reduce the severity of irrational pricing of shares is making the transparency of information by providing high-quality financial reporting. The quality of financial reports may have different aspects of the features, But two factors including timely and reliability of financial reports, are the most important component quality of the information. If the reports have been got faster to the investors and have higher reliability, it cause that the investors act more wisely in Pricing of shares. In this study, we investigated whether the timely and reliability of financial reporting, have an effect on the rational pricing of shares and earnings and its components, or not? When reporting of data will be timely, it will be more reliable, accounting profit figures also will have higher quality. In this study we have investigated the effect of Timely and reliability of information on the irrational pricing of shares with using of income and its components in the listed companies in Tehran Stock Exchange, during the period from 1381 to 1391. The results show that using of accounting earnings and its components caused to incorrect price of stock. But when timely and the reliability of financial reporting will be increases.

[Mohammad saadatniya, Mohammad Tamimi. The Study of Flatness and Timeliness of Financial Information on Pricing the irrational stock. N Y Sci J 2015;8(6):54-60]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 9

doi:10.7537/marsnys080615.09

 

Keywords: 'financial reports, operating cash flow, accruals, stock

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10

Investigation the relationship between attachment styles to God, with a tendency to drug addiction

 

Abbas Shahraki1, Narges Azadmanesh1, Dr. Mahvash Raghibi2, Eshrat Karimi Afshar1

 

1.  MSc in Clinical Psychology

2.  Associate Professor in University of Sistan and Baluchestan

 

Abstract: In this study, the relationships between styles of attachment to God with tendency to addiction of drugs were investigated. Number of 400 students of the University of Sistan and Baluchestan were selected by cluster sampling. Tools of this research are questionnaires of attachment style to God (Rovat and Kirkpatrick, 2002) and questionnaire of tend to addiction of drugs (Zargar, 2006). Styles of Attachment to God as predictor variables and tendency to addiction as variable of criterion were considered. Design of research is of correlation type and data of research with the Pearson correlation coefficient and stepwise regression analysis were analyzed. Results show existence of a negative correlation between secure attachment styles to God with desire to addiction. Also between avoidant secure attachment style to God and insecure ambivalent to God obtained positive correlation with the tendency to addiction. Coefficients of the regression analysis with method of stepwise entry show insecure avoidant style to God and insecure ambivalent to God are positive predictor for the tendency to addiction.

[Abbas Shahraki, Narges Azadmanesh, Mahvash Raghibi, Eshrat Karimi Afshar. Investigation the relationship between attachment styles to God, with a tendency to drug addiction. N Y Sci J 2015;8(6):61-64]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 10

doi:10.7537/marsnys080615.10

 

Keywords: attachment, addiction, drugs

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Erosion causes of Iran traditional and historical tissues and investigating intervention mechanisms in this tissues for their regeneration and revitalization

 

Arash Dideh Roshan

 

MSc in Architecture, Tehran University, Tehran, Iran

 

Abstract: Historical tissues of Iran Cities are valuable works that show culture, history, past architecture and urbanism knowledge of Iran city's society or in a clear expression, display identity and socio-cultural personality of Cities Iran. Iranian cities similar to many human artifacts in time catch erosion in the body and in some cases their performance. But attention to the reform and modernization of the city historic textures and, in general, interference in old textures always is being one of the major issues of historic cities and towns that have identify and specific morale. The most main objectives and fundamental strategies of interventionist activities for reform and modernization of historical textures are, returning it to cycle of life. Just with this target we can implement reform and modernization of historic tissues of Iran cities and guarantee the success of this matter. Lack of attention to the past, including historical and natural environment of tissues and building due to the various issues in addition to the heterogeny and creating chaos in the urban landscape, will be followed other consequences. Hence in this study initially was being tried to investigate causes and factors of the erosion of traditional tissues Iran and then is shown Strategies Facing with this inefficient and vulnerable tissues and as well as strategies preventing conditions creation of such tissues over time, with helping determined characteristics.

[Arash Dideh Roshan. Erosion causes of Iran traditional and historical tissues and investigating intervention mechanisms in this tissues for their regeneration and revitalization. N Y Sci J 2015;8(6):65-70]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 11

doi:10.7537/marsnys080615.11

 

Keywords: old Textures, reform, factors of erosion, overall design criteria, intervention in the tissues

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12

Stem Cell Debate Literatures

 

Ma Hongbao 1, Margaret Young 2, Yang Yan 1

 

1 Brookdale Hospital, Brooklyn, New York 11212, USA; 2 Cambridge, MA 02138, USA

ma8080@gmail.com

 

Abstract: The stem cell is the origin of an organism’s life that has the potential to develop into many different types of cells in life bodies. In many tissues stem cells serve as a sort of internal repair system, dividing essentially without limit to replenish other cells as long as the person or animal is still alive. When a stem cell divides, each new cell has the potential either to remain a stem cell or become another type of cell with a more specialized function, such as a red blood cell or a brain cell. This article introduces recent research reports in the stem cell debates as references.

[Ma H, Young M, Yang Y. Stem Cell Debate Literatures. N Y Sci J 2015;8(6):71-75]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 12

doi:10.7537/marsnys080615.12

 

Key words: stem cell; debate; life; research; literature

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[N Y Sci J 2015;8(6):76-79]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 13

 Withdrawn

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Study of restorative justice and distributive justice from the perspective of Islamic law and jurisprudence

 

Dr. Mohammad Ali Heidari1, Masoma Porshabanan2

 

1. Assistant Professor in Department of Law, Faculty of Law, Islamic Sciences and Theology, Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran

2. MSc in Islamic Sciences and Theology, Faculty of Law, Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran

 

Abstract: Theories of Explicit or implicit justice, rely on the philosophical presuppositions, epistemological and specific ethical and typically do not conceal this fact that suggest a model for social life that have recognized correct and right and the legitimacy and trueness is based on certain philosophical attitudes to human and community and ethics. Criminology theory of restorative criminal justice is of the most challenging focuses of interdisciplinary studies among Islamic teachings of criminal Jurisprudence with science modernism in the field of rights knowledge. The centrality of Islamic discourse of restorative justice based on principles and various installation including encouraging ignoring crime, forgiveness in suspended right of Allah and right of humans, modification of interpersonal, arbitration, intercession, the compensatory nature of the wergild, rule of repentance and indicates the ability of Islamic criminal policy in the implementation of restorative justice is devoid of defects which western criminal policy several decades after birth of criminology theory is facing with that defects. But distributive justice is economic and computational approach to criminal law and have humanist root and emphasizes on retribution, debilitation, remove of guilty from society and the associating goals of penalty to the financial cost and court and prison. This article after description of distributive justice and restorative justice, describes the origin, aspects and processes and effects of following of each country's penal system from each of these two huge paradigms and in the end, explains function of Islamic penalties in the suspended and nemesis and even some of penalties based on orbit of the  restorative justice, and distributive justice not in economic meaning of the word, but in the sense of retaliation and retribution commensurate with the crime is the characteristic of some other species of penalty in teachings of Islam criminal jurisprudence that of course with a particular reading has been entered in Iran's Islamic criminal laws.

[Mohammad Ali Heidari, Masoma Porshabanan. Study of restorative justice and distributive justice from the perspective of Islamic law and jurisprudence. N Y Sci J 2015;8(6):80-85]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 14

doi:10.7537/marsnys080615.13

 

Keywords: Restorative justice, distributive justice, leniency Islamic jurisprudence, the purpose of penalty, rehabilitation, relief of mind.

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15

Reveal and Conveyance in Unauthorized Sale

 

Mehrdad Kazemi

 

Department of law IslamAbad Gharb branch, Islamic Azad University, Islam Abad Gharb, Iran

And Department of Islamic Republic of Iran's the Judiciary, Judge Islamabad Garb, Iran

 

Abstract: Unauthorized sale is one of important issues on subject of sale and given that this sale integrity depends on permission, it is particularly important to describe permission status in unauthorized sale. In Fiqh (Religious Jurisprudence) terminology, sale is defined as transferring the object of property from one person to another, with Known return and parties’ consent (Sharh-e Lame). Unauthorized sale is one lacking element of owner permission. Instances of such a sale include usurped sale or sale without owner permission, fool sale and poor sale, in all cases of which sale is accurate and operative only by the owner permission. Permission takes different forms such as explicit permission, implicit permission and present witness. Islamic jurists have viewed unauthorized sale differently. Some attribute absolute integrity to unauthorized sale; a group regards it void; and others enlarge upon between sale and buying. Many scholars believe that unauthorized sale is accurate but with suspending integrity; this suspension and unauthorized sale reach certainty and perfect integrity, respectively, only through subsequent permission by owner. Permission status in unauthorized sale is perceived differently by different Islamic jurists because some argue that permission is an indication (revealer) in unauthorized sale, that is, as soon as the sale contract is concluded ownership is created but its rule is not revealed without permission. On the contrary, others believe in conveyance, considering permission as conveying. They argue that ownership is created after giving permission, not upon contract conclusion because a contract consists of elements without all of which it is not effective and operative.

[Mehrdad Kazemi. Reveal and Conveyance in Unauthorized Sale. N Y Sci J 2015;8(6):86-91]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 15

doi:10.7537/marsnys080615.14

 

Keywords: Reveal, Conveyance, Unauthorized Sale

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Cancer Genetics Research Literatures

 

Ma Hongbao 1, Margaret Ma 2, Yang Yan 1

 

1 Brookdale Hospital, Brooklyn, New York 11212, USA; 2 Cambridge, MA 02138, USA

ma8080@gmail.com

 

Abstract: Cancer is the general name for a group of more than 100 diseases. Although there are many kinds of cancer, all cancers start because abnormal cells grow out of control. Untreated cancers can cause serious illness and death. The body is made up of trillions of living cells. Normal body cells grow, divide, and die in an orderly fashion. During the early years of a person’s life, normal cells divide faster to allow the person to grow. After the person becomes an adult, most cells divide only to replace worn-out or dying cells or to repair injuries. This article introduces recent research reports in the cancer genetics related studies as references.

[Ma H, Young M, Yang Y. Cancer Genetics Research Literatures. N Y Sci J 2015;8(6):92-109]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 16

doi:10.7537/marsnys080615.15

 

Key words: cancer; genetics; research; literatures; life; cell

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Identification of Stem Cells in Liver Tissue of Patients with HCV-induced Chronic Liver Disease Versus Hepatocellular Carcinoma: Immunohistochemical Study

 

Mohammed S. Rozaek1, Elsayed G. Ammar1, Olfat A. Hammam3, Bahy EL Deen E. Elbahnasawy2, Mohmmed Salah Ali2, HendawyA.Zedan2, Hosam Eldeen S. Shabana2 and Farag Khalil1

 

Tropical Medicine Department1, Internal Medicine Department2, Faculty of Medicine, Al Azhar University, Egypt

Pathology DepartmentTheodorBilharz Research Institute3, Egypt

drsaidammar@yahoo.com

 

Abstract: Hepatitis C virus infection is a worldwide problem; people are chronically infected and at risk of developing liver diseases including cirrhosis and cancer. In recent years, a variety of stem cell markers such as CD34, CD133, CK7, CKl9, and OV6 have been found to be expressed in tumors along with intensive studies of stem cells, some of which are correlated with poor postoperative prognosis. High expression of OCT4 in tumors such as breast cancer, bladder cancer, and oral squamous cell carcinoma predicts a poor prognosis. Aim of the work-To evaluate hepatic expression of OV6, Cytokeratin 19 and (Oct3/4) in patients with HCV-induced chronic liver disease versus HCC and its correlation with the histologic activity, laboratory and clinical parameters. Patients and Methods: The present study was conducted on 75 selected patients and10 normal (age and sex matched) subjects were included as control group. The studied patients were divided into 4 groups: Group I: 20 patients with chronic viral hepatitis C. GroupII: 25 patients with post hepatitis (C) cirrhosis, GroupIII: 30 patients with hepatocellular carcinoma, Group IV: 10 healthy individuals as control., liver biopsies were taken from all groups and in control group from individuals subjected to cholecystectomy after receiving their consent. Immunohistiochemistry: Paraffin sections on positive charged slides were pretreated for antigen retrieval, then with supersensitive monoclonal human antibodies against OV6, CK19 and OCT3/4 with blockage of internal peroxidase activity. Streptavidin biotin peroxidase detection system was used, utilizing DAB as a chromogen and hematoxylin as a counter stain results. The mean values of OV6 level showed a highly significant increase in groups II and III compared to group I (p value < 0.01) and a highly significant increase in group III compared to group II (p value < 0.01). Tissue expression of CK19 were significantly increased in hepatitis, cirrhosis and HCC groups compared to control group (p value < 0.01), and there is significance in expression of CK19 in HCC compared to cirrhosis and hepatitis group (p value < 0.01). immunohistochemical stain OCT3/4 in HCC group revealed staining of OCT3/4 in all of HCC sections (83.3%) compared to cirrhotic (44%) and (20%) in hepatitis patients without cirrhosis while it was undetectable in normal control which is highly significant, also there is significant difference of tissue expression of OCT3/4 between different grades of HCC tissues.

[Mohammed S. Rozaek, Elsayed G. Ammar, Olfat A. Hammam, Bahy EL Deen E. Elbahnasawy Mohmmed Salah Ali, Hendawy A. Zedan, Hosam Eldeen S. Shabana and Farag Khalil. Identification of Stem Cells in Liver Tissue of Patients with HCV-induced Chronic Liver Disease Versus Hepatocellular Carcinoma: Immunohistochemical Study. N Y Sci J 2015;8(6):110-119]. (ISSN: 1554-0200). http://www.sciencepub.net/newyork. 17

doi:10.7537/marsnys080615.16

 

Key words: Stem Cells in Liver Tissue, HCV-induced Chronic Liver Disease, Hepatocellular Carcinoma: OV6, Cytokeratin 19 and OCT3/4Immunohistochemical

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The manuscripts in this issue were presented as online first for peer-review, starting from May 22, 2015

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