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Science Journal

 

New York Science Journal

(N Y Sci J)

ISSN 1554-0200 (print); ISSN 2375-723X (online), doi prefix: 10.7537, Monthly

Volume 11 - Number 1 (Cumulated No. 107); 25, 2018

Cover (jpg), Cover (pdf), Introduction, Contents, Call for Papers, ny1101

 
The following manuscripts are presented as online first for peer-review, starting from December 23, 2018. 
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CONTENTS  

No.

Titles / Authors /Abstracts

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1

Biological Monitoring of Polycyclic Aromatic Hydrocarbons as a Possible Risk Factor of Hepatocellular Carcinoma Among Cases of Chronic Active Hepatitis B and C

 

Raed M Alazab1, Alaa Abdelwahed1, Elham A Motawea2, Sherief A Morsy3, and Ahmed E Abd Raboh1

 

1Department of Community medicine and Occupational medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

2Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

3Hepatology and Gastroentrology Theodor Bilharz Research institute, Cairo, Egypt

raedelazab@hotmail.com, drahmedsayed2008@gmail.com

 

Abstract: Background: Polycyclic aromatic hydrocarbons (PAHs) are among the most carcinogenic, mutagenic and toxic contaminates. Their exposure and metabolism to DNA-reactive metabolites in the body are considered to contribute to the aetiology of many types of the human cancers. Objectives: to find out if exposure to polycyclic aromatic hydrocarbons is a risk factor for development of hepatocellular carcinoma among the exposed cases, to detect if the smoking is an augmented factor for development of hepatocellular carcinoma among exposed cases, and to find the effect of sociodemographic characteristics of cases of hepatocellular carcinoma exposed to hydrocarbons. Subjects and Methods: A case control study was conducted between the period from the first of March 2015 to end of August 2017. The study was conducted in the outpatient clinic of the Department of Hepatology and Gastro-entrology at Theodor Bilharz Research Institute (TBRI). The minimum sample size required for the present study was calculated using Epi info program, considering following data: Tow sided Confidence level = 95%, Power of test = 80%, Ratio of control: cases = 1:1, Percent of control exposed = 21%, Percent of cases exposed = 42 % and Odds ratio = 2.8. Kelsey estimated number of cases = 77 and number of control = 77 subjects. All subjects of both groups were interviewed. Every patient was subjected to the selected interview sheet and biological monitoring of urinary 1-hydroxy pyrene as a biomarker for PAHs exposure. Results: 73% of cases of HCC had increased level of 1-hydroxy pyrene in urine with statistical significance difference when compared to controls. There was significant positive association between exposure to PAHs and development of HCC among case group (OR = 4.9). There was significant association between smoking and abnormal high level of 1-hydroxy pyrene in urine (OR = 1.7), among the case group. There was significant positive association between exposure to PAHs and development of HCC among males (OR = 1.6). There was neither statistical significance difference nor positive association between exposure to PAHs and development of HCC in urban areas (OR=0.8). There was statistical significance positive association between exposure to PAHs and development of HCC among smoker (OR=1.7). There was neither statistical significance nor positive association between exposure to PAHs and development of HCC among patients with chronic active hepatitis C (OR=0.6). There was a highly positive correlation between 1-hydroxy pyrene and Alfa Feto Protein (AFP) among positive cases of 1-hydroxy pyrene in case group (OR=316.25). Recommendation: Prevention programs aimed to elimination of exposure to PAHs is needed. Environmental monitoring of PAHs in different residential areas in different governorates for detection of source of pollution with PAHs in air, soil and water is needed.

[Raed M Alazab, Alaa Abdelwahed, Elham A Motawea, Sherief A Morsy, and Ahmed E Abd Raboh. Biological Monitoring of Polycyclic Aromatic Hydrocarbons as a Possible Risk Factor of Hepatocellular Carcinoma Among Cases of Chronic Active Hepatitis B and C. N Y Sci J 2018;11(1):1-7]. ISSN 1554-0200 (print); ISSN 2375-723X (online). http://www.sciencepub.net/newyork. 1. doi:10.7537/marsnys110118.01.

 

Keywords: PAHs, 1-hydroxy pyrene

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2

Effectiveness of an Aerobic Training Program on some Physiological Variables and Social Acceptance among Females (40-50 years)

 

Nihad Moneer Othman Al-Bateky

 

Department of Health and Recreation, Faculty of Physical Education, University of Jordan, Jordan

dr.nihad_albatikhi@yahoo.com

 

Abstract: The current research aims to design an aerobic exercises program and identify its effects on: Physiological variables (pulse – blood pressure – fat percentage – muscles – bones – water – basic metabolic rate BMR – active metabolic rate AMR) for women (40-50 years) - 5HIAA concentrations in urine for women (40-50 years) - Responses to social acceptance scale for women (40-50 years) - Differences between measurements of all mentioned variables for women (40-50 years)‎. The researcher used the experimental approach (one-group design) with pre- and post-measurements. The researcher purposefully chose (10) women (40-50 years) who are newly participating in sport for health. Results indicated that: 1- The aerobic exercises program induced several physiological adaptive processes that can be measured after 6-8 weeks with no less than 25 minutes per session (3 times per week)‎. 2-Regular aerobic exercises have positive effects on improving the function of heart and this decreases heart rate 3- Aerobic exercises program decreased body fats through burning more calories and this decreases weight. In addition, it has positive effects on bone and muscle mass. This protects women in this critical age from osteoporosis although improvements did not reach calibration values. 4- Regular aerobic exercises decrease BMR and AMR due to energy saving in normal life. 5- Aerobic exercises program increased serotonin levels in the brain and this increase urine concentrations of 5HIAA which in turn has positive effects on mood. 6- Regular aerobic exercises improved responses to social acceptance scale and decreases vulnerability to depression due to increased levels of serotonin.

[Nihad Moneer Othman Al-Bateky. Effectiveness of an Aerobic Training Program on some Physiological Variables and Social Acceptance among Females (40-50 years). N Y Sci J 2018;11(1):8-15]. ISSN 1554-0200 (print); ISSN 2375-723X (online). http://www.sciencepub.net/newyork. 2. doi:10.7537/marsnys110118.02.

 

Key Words: Serotonin aerobic exercises physiological response social acceptance

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【N Y Sci J 2018;11(1):16-19]. ISSN 1554-0200 (print); ISSN 2375-723X (online). http://www.sciencepub.net/newyork. 3. doi:10.7537/marsnys110118.03.

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4

Bacteriological and molecular studies on Staphylococcus aureus isolated from mastitic cows

 

Abd El Hamid, T. M1, Sahar, R. Mohamed2, and I. A. Saleh3

 

1 Educational Hospital, Faculty of Veterinary Medicine, Cairo University, Egypt

2Animal Health Research Institute (Dokki branch), Egypt

3Faculty of Veterinary Medicine, Cairo University, Egypt

elerefaeytaher@yahoo.com

 

Abstract: Inflammation of mammary gland in bovines is frequently due to infection by Staphylococcus aureus which leads to appearance of clinical and subclinical mastitis in cattle. In this research the mastitic cases (103) were classified into clinical and subclinical cases (47,56) respectively. All milk samples collected from infected cows were subjected to bacteriological examination and molecular characterization of some Staphylococcus aureus isolates. Staphylococcus aureus was isolated from clinical and subclinical mastitic cows in an incidence of (50%, 17.5%) respectively. The application of multiplex PCR on some Staph. aureus isolates (8) was effectively in detection of, tst, hlg, clfA, nucgenes by amplification at a single amplicon at (326bp, 937bp, 638bp, 395bp respectively).

[Abd El Hamid, T. M, Sahar, R. Mohamed, and I. A. Saleh. Bacteriological and molecular studies on Staphylococcus aureus isolated from mastitic cows. N Y Sci J 2018;11(1):20-25]. ISSN 1554-0200 (print); ISSN 2375-723X (online). http://www.sciencepub.net/newyork. 4. doi:10.7537/marsnys110118.04.

 

Keywords: S.aureus- cows-mastitis-Pcr-virulence genes

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5

Radio-chemotherapy with Cisplatin, 5-Fluorouracil and Cetuximab for patients with locally advanced esophageal cancers

Chia-Wei Wu1,5, Hsiang-Chen Wang 2,5, Jen-Ming Tasi,1, and Chi-Ting Horng 3,4,*

1Department of Radiology, Kaohsiung Armed Forced General Hospital, Kaohsiung, Taiwan, ROC.
2Graduate Institute of Opto-Mechatronics, National Chung Cheng University, Chia-Yi, Taiwan, ROC.
3Department of Ophthalmology, Fooying University Hospital, Pingtung Taiwan, ROC.
4Department of Pharmacy, Tajen University, Pingtung, Taiwan, ROC.
5These authors contributed equally to the paper
E-mail: h56041@gmail.com; Telephone: 866-8-8323146

 

Abstract: Purpose: To evaluate the prognosis of patients with un-resectable locally advanced esophageal cancer who receiving radio-chemotherapy with 5-fluorouracil and cisplatin by addition of cetuximab. Besides, we aimed to define the maximum tolerated dose in the study. Methods: There were 6 victims of un-resectable locally advanced esophageal cancer were enrolled in this study who admitted to the Tri-Service General Hospital. The treatment regimen included 59.4 Gy of radiotherapy concurrently with two courses of cisplatin (20 mg/m, d1-4) and 5-FU (dose level 0:500 mg/m, dose level 1:750 mg/ m, d1-4; dose level 2: 1,000 mg/m, d1-4), followed by two courses of chemotherapy. In the meanwhile, cetuximab was given for 14 weeks (400 mg/m loading dose followed by 250 mg/m weekly). Result: At dose level 1(n=3) and 2 (n=3), no patient experienced the dose-limiting toxicity. Furthermore, minor treatment modifications were due to organization or request by physicians/patients. At dose level 2, only five grade 3 adverse events occurred. Conclusion: we concluded that the dose level 1 and 2 revealed safe and could be used in a subsequent randomized phase II in treat the patients with unresectable locally advanced esophageal cancer.
[Chia-Wei Wu, Hsiang-Chen Wang, Jen-Ming Tasi, and Chi-Ting Horng. Radio-chemotherapy with Cisplatin, 5-Fluorouracil and Cetuximab for patients with locally advanced esophageal cancers. N Y Sci J 2018;11(1):26-34]. ISSN 1554-0200 (print); ISSN 2375-723X (online). http://www.sciencepub.net/newyork. 5. doi:10.7537/marsnys110118.05.

Keywords: locally advanced esophageal cancer, chemoradiation

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6

Commuting Pattern and Transportation Challenges in Akure Metropolis, Ondo State, Nigeria

 

Gladys C. Emenike, Olabode S. Ogunjobi

 

Department of Geography and Environmental Management, University of Port Harcourt, Port Harcourt, Nigeria

gladysemenike@uniport.edu.ng

 

Abstract: Background: Many urban centers in Nigeria suffer from inadequate facilities that could ensure smooth urban movement. Introduction: The increase in commuting distance has impact on trip attraction, fares paid by commuters, traffic build-up in some land use areas; and shows the need for different modes of transportation. Aim of the study: The study examined the commuting pattern and transportation challenges in Akure Metropolis, Ondo State, Nigeria. Materials and methods: A total number of 398 copies of structured questionnaire were distributed to commuters along the selected roads (Oyemekun road, Ondo road, Oba Ile road, Arakale road, Oke Aro road, Hospital road, Ijoka road, Oda road, Danjuma road, and Sijuade road). Data obtained were analysed using descriptive and inferential statistics. Results: Findings showed that 52% were males and more than 70% of respondents were above 20 years. The mostly used type of transport in Akure City was public taxi (40.5%) and majority (49.7%) spent ≤ 30 minutes on the road before reaching their working place while the distance from home to work of more than 50% was ≤ 2km. The main trip purpose for commuters was education (33%) while most of the trips were made in the morning only (29.4%); and morning and evening (32.4%). However, 47.5% of commuters agreed that the peak hour of congestion is always between 7am and 9am. Findings also revealed that 55.3% agreed that the road conditions were not good while 31% and 26% of respondents agreed that the transport challenges were bad road and traffic congestion respectively. Among the selected roads, Oyemekun road (19.1%), Arakale road (12.8%) and Ijoka road (11.3%) were mostly prone to traffic congestion and the major causes of the traffic congestion were illegal parking (35.7%) and bad road (31.2%). Conclusion: Traffic congestion, bad road and illegal parking were the prominent problems along the road corridors and most trips are mostly generated for both educational and occupational reasons. Recommendations: The study therefore recommended among others that provision of off-street parking facilities in designated areas within Akure Metropolis is required and drainage facilities should be provided because of occasional flooding that may lead to the development of potholes on the roads.

[Gladys C. Emenike, Olabode S. Ogunjobi. Commuting Pattern and Transportation Challenges in Akure Metropolis, Ondo State, Nigeria. N Y Sci J 2018;11(1):35-41]. ISSN 1554-0200 (print); ISSN 2375-723X (online). http://www.sciencepub.net/newyork. 6. doi:10.7537/marsnys110118.06..

 

Keywords: Commuting pattern, Traffic congestion, Transportation challenges, Akure Metropolis

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7

Factors Affecting Outcome of Anti VEGF in Management of Diabetic Macular Edema

 

Mahmoud Ahmed kamal1, Amr Abd El Aziz Azab2, Ahmed Sayed Saif1, Mahrous Hassan Shaheen1

 

1Ophthalmology Department, Faculty of Medicine, Fayoum University, Egypt

2Research Institute of Ophthalmology, Egypt

mha13@fayoum.edu.eg

 

Abstract: Purpose: To evaluate Factors affecting outcome of intravitreal Anti VEGF (Ranibizumab) in the management of Diabetic Macular Oedema. Methodology: Twenty eyes of twenty patients were enrolled in the study. The patients received three monthly intra vitreal injection of 0.5mg /0.05ml ranibizumab. Inclusion criteria; Patients with diffuse diabetic macular edema with central macular thickness (CMT) >300um. Exclusion criteria; proliferative diabetic retinopathy, Cases with any macular disease other than diabetic maculopathy, Cases with history of cataract surgery within 12 months, Cases with significant cataract which interferes with OCT. Results: The mean CMT changed from 474.30 120.97um (319-680) at base line to 389.55 85.99um (287-600) at 6months. The mean BCVA (log MAR) changed from 0.97 0.19 at base line to 0.79 0.24 at 6months. Cases with interrupted ellipsoid zone showed poor functional response. HbA1c showed no correlation with the response. Conclusion: Ranibizumab is effective in treating DME. Outer retinal integrity in OCT is a predictor for response to treatment.

[Mahmoud Ahmed kamal, Amr Abd El Aziz Azab, Ahmed Sayed Saif, Mahrous Hassan Shaheen. Factors Affecting Outcome of Anti VEGF in Management of DME. N Y Sci J 2018;11(1):42-47]. ISSN 1554-0200 (print); ISSN 2375-723X (online). http://www.sciencepub.net/newyork. 7. doi:10.7537/marsnys110118.07.

 

Keywords: Factor; Affecting Outcome; VEGF; Management; Diabetic Macular Edema

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The manuscripts in this issue were presented as online first for peer-review, starting from  December 23, 2017. 

 All comments are welcome: newyorksci@sciencepub.net.

For back issues of the New York Science Journal, click here.

Emails:  newyorksci@sciencepub.net; editor@sciencepub.net

Website: http://www.sciencepub.net/newyork

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doi prefix: 10.7537

Global Impact Factor: 0.324 (2012); 0.435 (2013); 0.534 (2014); 0.654 (2015)

InfoBase Index IBI Factor: 4.89 (2015)

IF A2016: 3.62

, Root Indexing; Journal Index I2OR

 

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2018 Marsland Press