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Effect of nursing precision Health intervention on psychological distress and self-perceived burden in patients undergoing in vitro fertilization-embryo transfer

Guofeng Wu，Mengjie Li^*，Yanmei Li^*，Ping Zhu，Qifang Tang，Ni Luo，Zhaohui Jiang

The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning 530029, China

827666343@qq.com

Abstract：Objective​ To evaluate the effect of a precision nursing intervention based on the Nursing Science Precision Health (NSPH) model on psychological distress and self-perceived burden in patients undergoing in vitro fertilization-embryo transfer (IVF-ET), and to explore its impact on fertility knowledge level and quality of life. Methods This study was conducted in a public tertiary reproductive hospital in Guangxi Zhuang Autonomous Region. A total of 80 female patients undergoing IVF-ET were recruited and randomly divided into a control group (N=40) and an experimental group (N=40) using a random number table method. The control group received routine nursing care, while the experimental group received an additional NSPH model‑based precision psychological health intervention for 3 months. Patients' levels of psychological distress, self-perceived burden, fertility knowledge, and quality of life were assessed at baseline and 3 months after the intervention. Results After 3 months of intervention, the Distress Thermometer (DT) scores and Self-Perceived Burden Scale (SPBS) scores in the experimental group were significantly lower than those in the control group (all P < 0.05). The Fertility & Infertility Treatment Knowledge Score (FIT-KS) scores and all dimensions of the Fertility Quality of Life (FertiQoL) scale in the experimental group were also significantly better than those in the control group (all P < 0.05). Conclusion The precision nursing intervention based on the NSPH model can effectively reduce the level of psychological distress and self-perceived burden, and simultaneously improve fertility‑related knowledge and quality of life in IVF-ET patients. This intervention provides evidence‑based support for improving mental health outcomes in patients undergoing IVF-ET.

[Guofeng Wu，Mengjie Li，Yanmei Li，Ping Zhu，Qifang Tang，Ni Luo，Zhaohui Jiang. Effect of nursing precision Health intervention on psychological distress and self-perceived burden in patients undergoing in vitro fertilization-embryo transfer. Biomedicine and Nursing 2026;12(3):1-10]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 01. doi:10.7537/marsbnj120326.01

Keywords: In vitro fertilization-embryo transfer; Nursing Science Precision Health model; Psychological distress; Self-perceived burden; Randomized controlled trial; Quality of life；Nursing

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REVIEW ON BOVINE TUBERCULOSIS AND ITS PUBLIC IMPORTANCE

Hissa Dingeta Taressa, Asmamaw Aki* and Ramadan Teshome

Kondala Woreda Agriculture and Land  office, Animal Health Department head, Disease Prevention and control  Expert, West Wollega Zone, Oromia Regional State, Ethiopia

Assosa Regional, Animal Health Diagnostic Laboratory, P.O.BOX 326, cell phone +251-902330029, asmamawaki@gmail.com

Mutsa Kebele Veterinary Clinic, Bambasi District Agriculture,Assosa Zone, Benishangul Gumuz Regional State.

SUMMARY: Tuberculosis is primarily transmitted from infected animals to humans through close contact and the ingestion of raw animal products, especially unpasteurized milk from diseased animals. While Mycobacterium bovis predominantly affects members of the Bovidae family, it can also infect humans. Bovine tuberculosis (bTB) is a zoonotic disease that incurs significant economic burdens due to costly eradication programs and complicates the movement of animals and their products. This chronic infectious disease is characterized by the formation of granulomas in various tissues, particularly the lungs, lymph nodes, liver, intestines, and kidneys. The main etiological agent, Mycobacterium bovis, is an acid-fast bacterium distinguished by the presence of mycolic acid in its cell wall. Transmission occurs through both aerogenous and enterogenous routes. Although M. bovis is not the primary cause of human tuberculosis, it still poses a threat to human health through the consumption of raw milk, meat, and other products from infected animals or via inhalation of infectious droplets. In Ethiopia, bovine tuberculosis is endemic, with transmission primarily occurring through the ingestion of unpasteurized contaminated milk and contact with infected animals. The disease is associated with the development of miliary tubercular lesions, chronic cough, obstructions of air passages, and enlargement of lymph nodes. The objective of this review is to highlight the significance of tuberculosis as a critical bacterial disease affecting both humans and animals worldwide, with a particular focus on its complex and multi-species nature, including bovine, avian, and human TB.

[Hissa Dingeta Taressa, Asmamaw Aki and Ramadan Teshome. REVIEW ON BOVINE TUBERCULOSIS AND ITS PUBLIC IMPORTANCE. Biomedicine and Nursing 2026;12(3):11-23]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 02. doi:10.7537/marsbnj120326.02

Keywords:  Bovine; Ethiopia Mycobacterium Bovis; Zoonotic Disease

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ASSESSMENT OF COMMUNITY KNOWLEDGE, ATTITUDE AND PRACTICE ON RABIES IN KONDALA DISTRICT, OROMIA REGIONAL STATE, WESTERN ETHIOPIA

Hissa Dingeta Taressa, Asmamaw Aki* and Ramadan Teshome

Kondala Woreda Agriculture and Land  office, Animal Health Department head, Disease Prevention and control  Expert, West Wollega Zone, Oromia Regional State, Ethiopia

*Assosa Regional, Animal Health Diagnostic Laboratory, P.O.BOX 326, cell phone +251-902330029, asmamawaki@gmail.com

Mutsa Kebele Veterinary Clinic, Bambasi District Agriculture,Assosa Zone, Benishangul Gumuz Regional State.

ABSTRACT: Rabies remains a significant public health challenge in Ethiopia, with the country recording the second-highest number of human fatalities in Africa. Despite being preventable, low community awareness and inadequate preventive practices perpetuate its endemicity. This cross-sectional study assessed the knowledge, attitudes, and practices of households in the community with related to rabies in Kondala District, Western Ethiopia, from November 2024 to June 2025.  In the present study, a structured questionnaire survey was used. 200 participants were selected through multi stage sampling methods in the Gaba Dafino 01 and 02 kebeles. Data were analyzed using STATA version 17, with multivariate binary logistic regression models identifying associations among variables. Result revealed that, majority of respondents (57.5%, 58.5%) were males and 15–30 years‘ age respectively. Only 52% has awareness of rabies, and misconceptions about transmission and distribution of diseases, with 70% erroneously believing consumption of infected meat, spreads the disease. Whereas, the dominant (100%) respondents, understand as post-exposure prophylaxis prevent rabies after a bite, and 56% were aware of dog vaccination.  With respect to attitudes, 98% of the participant interviewers recognized rabies as fatal if untreated early, while 5.5% perceived it as a serious community threat. Community practices were inadequate, with 88% failing to vaccinate dogs and 60% relying on herbal remedies after bites. Multivariable analysis identified younger age (Adj. OR=13.076, p =0.001), higher education (Adj. OR = 24.504, p =0.004), and male gender (Cr OR=2.512, p=0.003) as significant predictors of better preventive practices. The overall KAP scores indicated 68.5% had good knowledge, 65.5% positive attitudes, and 68% acceptable practices. The study underscores critical gaps in rabies awareness, particularly among older, less educated, and female populations. Therefore, targeted interventions, including community education, improved vaccine accessibility, and inter - sectorial collaboration, are urgently needed to enhance rabies control in Kondala District. These findings provide a foundation for public health strategies to reduce rabies-related morbidity and mortality in rural Ethiopia. 

[Hissa Dingeta Taressa, Asmamaw Aki and Ramadan Teshome. ASSESSMENT OF COMMUNITY KNOWLEDGE, ATTITUDE AND PRACTICE ON RABIES IN KONDALA DISTRICT, OROMIA REGIONAL STATE, WESTERN ETHIOPIA. Biomedicine and Nursing 2026;12(3):24-42]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 03. doi:10.7537/marsbnj120326.03

Keywords: Attitude; Ethiopia; Knowledge; Kondala; Practice; Rabies

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SEROEPIDEMIOLOGICAL ANALYSIS OF PAST HUMAN CYTOMEGALOVIRUS INFECTIONS AMONG HIV-INFECTED INDIVIDUALS ATTENDING A HOSPITAL IN RIVERS STATE, NIGERIA

^*1Dibia, C. S., ¹Frank-Peterside, N., ¹Onyedibia, G., ²Okonko, B. J. & ¹Okonko, I. O.

¹Virus & Genomics Research Unit, Department of Microbiology, University of Port Harcourt, Port Harcourt, Nigeria.

²Medical Microbiology & Epidemiology Research Unit, Department of Microbiology, Madonna University Nigeria, Elele, Rivers State, Nigeria.

*Corresponding author’s E-mail address: constance_smith@uniport.edu.ng

ABSTRACT: The human Cytomegalovirus (HCMV) is an important opportunistic pathogen that accelerates disease progression in HIV-infected individuals globally, which contributes to a high rate of morbidity, mortality, HIV acquisition and disease progression. This qualitative cross-sectional study analysed plasma samples from 93 HIV positive subjects visiting a health institution in Rivers State, Nigeria. The study aimed to investigate the burden and associated factors of human cytomegalovirus (HCMV) co-infection among HIV-infected individuals in Rivers State. Plasma samples were screened via serology for the presence of specific HCMV IgG antibodies using ELISA kits. Socio-demographic characteristics of the subjects were collected by the use of a structured questionnaire. Chi-square test was used to assess the statistical significance of different socio-demographic factors to HCMV acquisition. All 93 subjects (100%) were seropositive for HCMV IgG antibodies. No statistical association existed between the prevalence of HCMV IgG antibodies and the socio-demographic factors studied, except the educational level (p=0.147). Higher prevalence of HCMV IgG antibody was found in the age group 25-44 years, 75(80.6%), female gender 54(58.1%), single marital status 44(47.3%), secondary education 31(33.3%), self-employed 51(54.8%), Christians 82(88.2%) and ART use 92(98.9%). The high seropositivity of HCMV IgG antibody in this study is an indication that there had been a past HCMV infection among the study population, which necessitates the need for serological evaluation in all HIV-infected individuals to avoid reactivation of HCMV coinfection.

[Dibia, C. S., Frank-Peterside, N., Onyedibia, G., Okonko, B. J. & Okonko, I. O. Seroepidemiological Analysis of Past Human Cytomegalovirus Infections among HIV-Infected Individuals attending a Hospital in Rivers State, Nigeria. Biomedicine and Nursing 2026;12(3):43-47]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 04. doi:10.7537/marsbnj120326.04

Keywords: HCMV; HIV; Coinfections; IgG; ELISA; antibodies

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Evaluation of Tetanus Toxoid Vaccine Potency and Antibody Response to Routine Vaccination among a Population of Rivers State, Nigeria

¹Ugboma, C. D., ²Okonko, B. J., ¹Cookey, T. I., ³Awanye, A. M, ¹Frank-Peterside, N. & ¹Okonko, I. O.

¹Virus & Genomics Research Unit, Department of Microbiology, University of Port Harcourt, Choba, Nigeria.

²Medical Microbiology & Epidemiology Research Unit, Department of Microbiology, University of Port Harcourt, Nigeria

³Immunology and Vaccinology Research Unit, Department of Pharmaceutical Microbiology & Biotechnology, University of Port Harcourt, Nigeria

Correspondence Author email address: chizoba_ugboma@uniport.edu.ng

ABSTRACT: The study evaluates vaccine potency and investigates the prevalence of IgG antibodies for tetanus toxoid (TT) in routine vaccination among a population of Rivers State, Nigeria, with socio-demographic factors. Using ELISA kits, the study analysed blood samples from 282 participants, aiming to evaluate immunity levels against tetanus. The overall antibody response prevalence was 90.3%. Participants aged 21-30 years were again the majority (55.6%), and females constituted 93.2%. Married individuals accounted for 79.4% of the group, with 54% holding a tertiary education. Most were involved in business (45%) or civil service (39%). The clinical presentations predominantly showed pregnant women (76.2%) and an even distribution across gestational periods. The study revealed a significant prevalence of Tetanus Toxoid IgG antibodies, particularly among females (93.2%) and urban residents (91.3%). This highlights the effectiveness of vaccination programs in these groups and the need to sustain high immunity levels to prevent tetanus outbreaks, especially among women of reproductive age. The study highlighted lower tetanus immunity levels in rural populations (8.7%) and males (6.8%), underscoring the need to focus public health efforts on improving vaccine coverage in these underserved groups. The study found that 76.2% of the participants were pregnant women, emphasising the critical role of tetanus vaccination during pregnancy to prevent neonatal tetanus. This reinforces the importance of maternal health interventions in ensuring adequate tetanus protection. Education level, marital status, and occupation were found to influence tetanus immunity. Higher levels of immunity were associated with tertiary education (54%) and certain occupations like business/traders (45%) and civil servants (39%). These findings contribute to understanding how socio-demographic factors impact vaccination uptake and immunity. The study emphasises the importance of monitoring tetanus toxoid immunity, particularly among pregnant women, as a significant proportion (65.8%) reported pregnancy. The major conclusion from the study is that young, urban-dwelling women of reproductive age, particularly those aged 21-30, exhibit high antibody prevalence for tetanus. This finding contributes to understanding vaccine efficacy and the need for targeted immunisation programs, particularly in maternal health contexts.

[Ugboma, C. D., Okonko, B. J., Cookey, T. I., Awanye, A. M., Frank-Peterside, N., & Okonko, I. O.  Evaluation of Tetanus Toxoid Vaccine Potency and Antibody Response to Routine Vaccination among a Population of Rivers State, Nigeria. Biomedicine and Nursing 2026;12(3):48-62]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 05. doi:10.7537/marsbnj120326.05

Keywords: Tetanus; Toxoid; IgG Antibody; Maternal Health

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Review On: Food Chain Flow Diagram And Pathogen Control In Each Node

Hissa Dingeta Taressa  and Asmamaw Aki

kondala Woreda Agriculture office, West Wollega Zone Oromia Regional State, Western Ethiopia

BGRS, BOA regional Animal Health Diagnostic  Laboratory, P.O. BOX, 326. phone +251902330029,  asmamawaki@gmail.com

Summary: The presence of microorganisms in food poses a significant threat to public health, as it can result in foodborne illnesses with serious consequences for individuals and communities. The significance of food safety management, as demonstrated in this review, is paramount in the prevention and control of pathogenic microorganisms within the food supply chain, thereby ensuring public health. Food safety management is crucial for preventing and controlling pathogenic microorganisms in food. Collaboration across the food chain, from production to consumption, is essential for effective management strategies.  Factors like temperature, pH, and water activity, alongside advanced identification techniques, play key roles in microbial control.  Consumer education is essential in promoting safe food handling practices, thereby reducing foodborne illnesses and reinforcing confidence in the food system. In conclusion, the continuous evolution of practices, technologies, and regulations in this field drives the provision of safe, healthy, and high-quality food products, thus fulfilling the crucial mission of food safety management in contemporary society.

[Hissa Dingeta Taressa  and Asmamaw Aki. Review On: Food Chain Flow Diagram And Pathogen Control In Each Node. Biomedicine and Nursing 2026;12(3):63-67]. ISSN 2379-8211 (print); ISSN 2379-8203 (online). http://www.nbmedicine.org. 06. doi:10.7537/marsbnj120326.06

Key words:  Food; Food safety management; foodborne;  food chain

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